UNC2025 2HCl (1429881-91-3(free base))

SKU: orb1302875

Description

UNC2025 is a potent, orally active small molecule that dually inhibits Mer and Flt3 tyrosine kinases with sub-nanomolar IC50 values. It is a valuable research tool for studying oncology and immuno-oncology, demonstrating efficacy in both cellular assays and in vivo tumor models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• MW: 549.62
• Purity: 98.56% (May vary between batches)
• Formula: C₂₈H₄₂Cl₂N₆O
• SMILES: Cl.Cl.CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
• Target: FLT,TAM Receptor
• Solubility: DMSO:5.5 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  Mer:0.8 nM|FLT3:0.74 nM
• In Vivo:
  UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mer, Flt3, TAM Receptor, TAMReceptor, UNC2025 2HCl (1429881 91 3(free base)), UNC2025 2HCl (1429881913(free base)), UNC-2025 2HCl (1429881-91-3(free base)), UNC2025 2HCl (1429881-91-3(free base))

Compound Identifiers

PubChem CID

133640205