UNC0379 TFA

SKU: orb1686333

Description

UNC0379 TFA is a potent and selective substrate-competitive inhibitor of the lysine methyltransferase SETD8 (KMT5A), with an IC50 of 7.3 µM. It demonstrates high selectivity over 15 other methyltransferases. This compound is a valuable chemical probe for studying histone H4 lysine 20 methylation in epigenetic and cancer research, both in vitro and in cellular assays.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation

Key Properties

• CAS Number: 1620401-83-3
• MW: 527.589
• Formula: C₂₅H₃₆F₃N₅O₄
• SMILES: OC(=O)C(F)(F)F.COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1
• Target: Others,Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

92044361