UNC0379

SKU: orb1307344

Description

UNC0379 is a potent and selective inhibitor that targets the SETD8 methyltransferase through a substrate-competitive mechanism. This tool compound is widely used in biochemical and cellular research to probe the biological functions of histone H4 lysine 20 methylation in processes such as DNA damage repair and cell cycle regulation.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1620401-82-2
• MW: 413.56
• Purity: 98.11%
• Formula: C₂₃H₃₅N₅O₂
• SMILES: COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1
• Target: Histone Methyltransferase
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:76 mg/mL (183.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.84 mM)

Bioactivity

• Target IC50:
  SETD8:7.3 μM
• In Vitro:
  UNC0379 is competitive with the peptide substrate and noncompetitive with the cofactor SAM.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OVCAR3, Ovarian cancer, neuroblastoma, lysine methyltransferase, JHOS3, inhibit, Inhibitor, HGSOC, HistoneMethyltransferase, Histone Methyltransferase, antitumor, SETD8, pulmonary fibrosis, UNC0379, UNC-0379, UNC 0379

Compound Identifiers

PubChem CID

78357767