UNC0321

SKU: orb1307632

Description

UNC0321 is a potent and selective small-molecule inhibitor of the histone methyltransferases G9a (Ki = 63 pM) and GLP. It is a valuable chemical probe for epigenetic research, enabling the study of histone methylation's role in gene expression, cellular differentiation, and disease models in both in vitro and in vivo settings.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1238673-32-9
• MW: 515.69
• Purity: 99.80% (May vary between batches)
• Formula: C₂₇H₄₅N₇O₃
• SMILES: COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCOCCN(C)C)N1CCCN(C)CC1
• Target: Apoptosis,Glucagon Receptor,Histone Methyltransferase
• Solubility: DMSO:3.33 mg/mL (6.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.94 mM)

Bioactivity

• Target IC50:
  GLP:15-23 nM|G9a:63 pM （ki）|G9a:6-9 nM
• In Vitro:
  UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E. UNC0321 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, K373, p53, G9a, GLP, H3K9, H3K9me2, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, PKMT, SAR, quinazoline, UNC 0321, UNC0321, UNC-0321

Compound Identifiers

PubChem CID

46901937