UNC 669

SKU: orb1305890

Description

UNC 669 is a potent and selective small-molecule inhibitor of the MBT domain proteins L3MBTL1 and L3MBTL3, exhibiting IC50 values of 4.2 µM and 3.1 µM, respectively. This chemical probe is used in vitro to study chromatin regulation and transcriptional repression in cancer research, particularly for investigating malignant brain tumor (MBT) family function.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1314241-44-5
• MW: 338.24
• Purity: 97.40%
• Formula: C₁₅H₂₀BrN₃O
• SMILES: Brc1cncc(c1)C(=O)N1CCC(CC1)N1CCCC1
• Target: Epigenetic Reader Domain
• Solubility: DMSO:9 mg/mL (26.61 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.96 mM);Ethanol:63 mg/mL (186.26 mM)

Bioactivity

• Target IC50:
  L3MBTL1:4.2 μM|L3MBTL3:3.1 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L3MBTL3, L3MBTL4, L3MBTL1, MBT, Epigenetic Reader Domain, EpigeneticReaderDomain, inhibit, Inhibitor, transcriptional, repression, repeats, UNC669, UNC-669, UNC 669

Compound Identifiers

PubChem CID

46931242