UNC 1062

SKU: orb1819247

Description

UNC1062 is a potent and highly selective MERTK tyrosine kinase inhibitor, with an IC50 of 1.1 nM. It demonstrates functional activity in vitro by inhibiting melanoma cell proliferation, colony formation, and invasion, and shows selectivity over related TAM family kinases TYRO3 and AXL.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1350549-36-8
• MW: 514.64
• Purity: 99.60% (May vary between batches)
• Formula: C₂₅H₃₄N₆O₄S
• SMILES: CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
• Target: TAM Receptor,Others
• Solubility: DMSO:55 mg/mL (106.87 mM)

Bioactivity

• In Vitro:
  UNC1062 potently inhibits MERTK kinase activity in vitro (MERTK IC50 = 1.1 nM, Morrison Ki = 0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC50 = 60 nM, AXL IC50 = 85 nM). Treatment of HMCB and G361 cells with increasing concentrations of UNC1062 resulted in a potent dose-dependent reduction in MERTK phosphorylation.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UNC1025, UNC-1025, UNC 1025, MERTK

Compound Identifiers

PubChem CID

68212798