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UNC-0642

SKU: orb1223285

Description

UNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. UNC0642 exhibits an in vitro IC50 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. In cells, UNC0642 results in a potent reduction of H3K9me2 in MDA MB231 cells with IC50 = 106 nM.

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Key Properties

CAS Number1481677-78-4
MW546.69
Purity>98% (HPLC)
FormulaC29H44F2N6O2
SMILESCC(N1CCC(Nc2c3cc(OC)c(OCCCN4CCCC4)cc3nc(N3CCC(F)(F)CC3)n2)CC1)C
TargetSigma receptor
SolubilityDMSO : 295 mg/mL. 539.60 mM;

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AHU-377

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Protocol Information

UNC-0642 (orb1223285)

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Available Sizes

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500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 200.00
25 mg
$ 340.00
50 mg
$ 540.00
100 mg
$ 790.00
200 mg
$ 1,140.00