Umbralisib tosylate

SKU: orb1744885

Description

Umbralisib Tosylate (TGR-1202) is an orally active, dual inhibitor of PI3Kδ (EC50=22.2 nM) and CK1ε. It exhibits unique immunomodulatory effects on T-cells and is used in research for hematological malignancies, including in vitro and in vivo studies for chronic lymphocytic leukemia (CLL).

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1532533-72-4
• MW: 743.75
• Formula: C₃₈H₃₂F₃N₅O₆S
• SMILES: S(=O)(=O)(O)C1=CC=C(C)C=C1.NC1=C2C(=NN([C@@H](C)C3=C(C(=O)C=4C(O3)=CC=C(F)C4)C5=CC(F)=CC=C5)C2=NC=N1)C6=CC(F)=C(OC(C)C)C=C6
• Target: Others,PI3K,Casein Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

86707828