UM-203

SKU: orb3173943

Description

UM-203 is a reversible covalent STING antagonist effective against both mouse and human STING. It is particularly potent in inhibiting the common human STINGR232 variant. UM-203 prevents STING oligomerization and decreases the phosphorylation of downstream TBK1 and IRF3, thereby blocking the signaling pathways mediated by IRF3 and NF-κB, and inhibiting the secretion of IFNβ and IL-6. UM-203 is useful for research in inflammation and immunology, such as systemic lupus erythematosus.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• Target: IFNAR,IκB/IKK,STING,NF-κB,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IFNAR,IκB/IKK,STING,NF-κB,Interleukin