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ULK1-IN-4

SKU: orb3211196

Description

ULK1-IN-4 (compound 12i) is a ULK1 inhibitor with an IC50 of 4.7 μM for human ULK1, and it exhibits selectivity for Aurora A/Aurora B kinases. It forms a covalent bond with the thiol group of the Cys182 residue in ULK1, thereby inhibiting its kinase activity. ULK1-IN-4 can suppress the growth of colorectal cancer cells and demonstrates tumor inhibitory activity in a mouse model of colorectal cancer.

Images & Validation

Key Properties

TargetAutophagy

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information