ULK1-IN-2

SKU: orb1686700

Description

ULK1-IN-2 is a potent and selective ULK1 inhibitor that induces apoptosis and blocks autophagy, demonstrating high cytotoxicity (IC50 = 1.94 µM in A549 cells). It is a valuable chemical probe for studying autophagy-dependent processes in non-small cell lung cancer research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 2497409-01-3
• MW: 495.26
• Purity: 99.97% (May vary between batches)
• Formula: C₁₉H₁₆BrFN₄O₆
• SMILES: O(C)C1=C(OC)C=C(NC=2N=C(OC3=C(F)C=C(N(=O)=O)C=C3)C(Br)=CN2)C=C1OC
• Target: Autophagy,FAK,Apoptosis,AMPK
• Solubility: DMSO:45 mg/mL (90.86 mM)

Bioactivity

• In Vitro:
  ULK1-IN-2 (compound 3s) (10 μM; 24 h) exhibits potent anti-proliferative activity against A549, U937, HL60, MDA-MB-468, and MCF-7 cells. In A549 cells, ULK1-IN-2 inhibits autophagy by targeting ULK1 and induces apoptosis via mitochondrial pathways in a dose-dependent manner. It also reduces ULK1 and p-ULK1ser317 expression in a concentration-dependent manner, significantly decreasing Bcl-2 expression while increasing Bax and active Caspase-3 expression.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, ULK1

Compound Identifiers

PubChem CID

162658365