Ulipristal

SKU: orb1300531

Description

Ulipristal acetate is a selective progesterone receptor modulator (SPRM) used for emergency contraception. It is widely employed in reproductive biology research to study progesterone receptor signaling, with applications in both in vitro receptor binding assays and in vivo models of uterine function.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 159811-51-5
• MW: 433.58
• Purity: 99.90% (May vary between batches)
• Formula: C₂₈H₃₅NO₃
• SMILES: [H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C
• Target: Estrogen/progestogen Receptor,Progesterone Receptor
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (126.85 mM);Ethanol:12 mg/mL (27.68 mM)

Bioactivity

• In Vivo:
  Based on clinical trials, ulipristal acetate seems to be a reasonably tolerable and effective method of emergency contraception when used within 120 hours of intercourse. Ulipristal acetate is at least as effective as LNG when used within the first 72 hours after unprotected intercourse. However, ulipristal acetate may be more effective than LNG when used between 72 to 120 hours after unprotected intercourse, extending the window of opportunity for emergency contraception.
  Read more...
• In Vitro:
  Ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to theglucocorticoid receptor, but has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

contraception, CDB 3236, CDB3236, CDB-3236, Deacetyl CDB 2914, Deacetyl CDB2914, Deacetyl CDB-2914, anti-fertility, anti-glucocorticoid, anti-progestational, inhibit, NR3C3, Inhibitor, leiomyoma, EstrogenReceptor, Estrogen Receptor, emergency, PR, ProgesteroneReceptor, Progesterone Receptor, progestogenReceptor, progestogen Receptor, Ulipristal, uterine

Compound Identifiers

PubChem CID

13559281