UK122 hydrochloride

SKU: orb3174726

Description

UK122 hydrochloride is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA), exhibiting an IC50 value of 0.2 μM. UK122 hydrochloride demonstrates minimal inhibitory activity against tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin, with IC50 values greater than 100 μM for all. As a 4-oxazolidinone analog, UK122 hydrochloride inhibits cancer cell migration and invasion. The selectivity profile of UK122 hydrochloride supports the application of UK122 hydrochloride in research focused on protease biology, extracellular matrix remodeling, tumor cell invasion, and metastatic mechanisms.

Research Area

Protein Biochemistry

Key Properties

• MW: 327.77
• Formula: C₁₇H₁₄ClN₃O₂
• SMILES: O=C(O1)/C(N=C1C2=CC=CC=C2)=C\C3=CC=C(C(N)=N)C=C3.Cl
• Target: Serine Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Serine Protease