UK-371804 HCl

SKU: orb1704783

Description

UK-371804 is a highly potent and selective small molecule inhibitor of urokinase-type plasminogen activator (uPA), exhibiting a Ki of 10 nM. It demonstrates significant selectivity, being 2700-fold more selective against plasmin and 4000-fold against tissue-type plasminogen activator (tPA). This inhibitor is a valuable research tool for studying uPA's role in cancer cell invasion, metastasis, and angiogenesis in both in vitro and in vivo models.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 256476-36-5
• MW: 422.29
• Formula: C₁₄H₁₇Cl₂N₅O₄S
• SMILES: Cl.CC(C)(NS(=O)(=O)c1ccc2c(Cl)cnc(NC(N)=N)c2c1)C(O)=O
• Target: Serine Protease,PAI-1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

16657953