UF010

SKU: orb1304426

Description

UF010 is a potent and selective HDAC inhibitor, demonstrating highest potency against HDAC3 (IC50 ~0.06 µM) followed by HDAC2, HDAC1, and HDAC8. This small molecule is a valuable research tool for studying epigenetic mechanisms in cancer, neuroscience, and inflammation in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 537672-41-6
• MW: 271.15
• Purity: 98.03% (May vary between batches)
• Formula: C₁₁H₁₅BrN₂O
• SMILES: CCCCNNC(=O)c1ccc(Br)cc1
• Target: HDAC,JAK,MyD88,NF-κB,TLR,Interleukin
• Solubility: DMSO:75 mg/mL (276.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.38 mM)

Bioactivity

• Target IC50:
  HDAC1:0.5 μM|HDAC2:0.1 μM|HDAC6:18.93 μM|HDAC8:1.5 μM|HDAC3:0.06 μM
• In Vivo:
  The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections1.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UF 010, UF010, UF-010, inhibit, Inhibitor, Histone deacetylases, HDAC

Compound Identifiers

PubChem CID

4596836