UCM05

SKU: orb1704952

Description

UCM05 (G28UCM) is a dual-function small molecule that potently inhibits fatty acid synthase (FASN), demonstrating efficacy in HER2+ breast cancer models, including therapy-resistant lines [1]. It also acts as a bacterial FtsZ inhibitor, selectively targeting Gram-positive B. subtilis with a MIC of 100 μM [2]. This compound is a valuable research tool for oncology and antibacterial studies.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1094451-90-7
• MW: 464.38
• Purity: 99.25% (May vary between batches)
• Formula: C₂₄H₁₆O₁₀
• SMILES: Oc1cc(cc(O)c1O)C(=O)Oc1cc(OC(=O)c2cc(O)c(O)c(O)c2)c2ccccc2c1
• Target: Fatty Acid Synthase,Antibiotic,Antibacterial
• Solubility: DMSO:90 mg/mL (193.81 mM);Ethanol:Soluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.11 mM)

Bioactivity

• In Vivo:
  G28UCM (40 mg/Kg; Daily i.p; for 45 days) inhibits the growth of BT474 xenografts and do not induce weight loss in vivo.
• In Vitro:
  G28UCM shows cytotoxic activity in developed HER2 + and FASN + trastuzumab and lapatinib-resistant cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UCM-05, UCM05, UCM 05, G28UCM, FattyAcidSynthase, Fatty Acid Synthase, Fatty Acid Synthase (FASN)

Compound Identifiers

PubChem CID

24896615