UCM-1336

SKU: orb1297787

Description

UCM-1336 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 2 µM. This small molecule is a valuable research tool for studying Ras protein maturation and function in both cellular and animal models of oncology and related signaling pathways.

Research Area

Cell Biology

Key Properties

• CAS Number: 1621535-90-7
• MW: 423.59
• Purity: 98.86% (May vary between batches)
• Formula: C₂₆H₃₇N₃O₂
• SMILES: N(C(CCN(CCC(NC1=CC=CC=C1)=O)CCCCCCCC)=O)C2=CC=CC=C2
• Target: Autophagy,Apoptosis,Others
• Solubility: DMSO:11 mg/mL (25.97 mM)

Bioactivity

• Target IC50:
  ICMT:2 μM
• In Vivo:
  UCM-1336 significantly inhibits glioblastoma growth without causing toxicity in mice.
• In Vitro:
  UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. UCM-1336 induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. Because ICMT inhibition impairs the activity of the four Ras isoforms regardless of its activating mutation, UCM-1336 surmounts many of the common limitations of available Ras inhibitors described so far.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

isoprenylcysteine carboxylmethyltransferase (ICMT), 3,3′-(Octylimino)bis[N-phenylpropanamide], UCM1336, UCM-1336, UCM 1336

Compound Identifiers

PubChem CID

71656043