UCL-TRO-1938

SKU: orb2278877

Description

UCL-TRO-1938 is a subtype-selective allosteric activator of PI3Kα, demonstrating cardioprotective and neuroregenerative properties. It is utilized in research on diseases involving aberrant PI3Kα signaling, with applications in studying cell proliferation and conducting in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2919575-27-0
• MW: 456.58
• Purity: 99.95% (May vary between batches)
• Formula: C₂₇H₃₂N₆O
• SMILES: O=C(N1C=2C(=CC=CC2CC1)NC=3C=CN=C(C3)NC4=CC=C(C=C4)N5CCN(CC)CC5)C
• Target: PI3K,Akt
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.38 mM);DMSO:40 mg/mL (87.61 mM)

Bioactivity

• In Vivo:
  Male C57/BL6 mice weighing 25-30 g were used throughout. 10 mg/kg UCL-TRO-1938 compound in DMSO. UCL-TRO-1938 provided significant cardioprotection in an in vivo IRI model in mice, with a corresponding pAKTS473 increase in the hearts.
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• In Vitro:
  In PI3Kα-WT but not in PI3Kα-KO MEFs, 24h treatment with UCL-TRO-1938 dose-dependently increased metabolic activity, with an EC50 of ~0.5 μM, and a decrease in ATP levels in both PI3Kα-WT and PI3Kα-KO MEFs at concentrations >7.5 μM, indicative of PI3Kα-independent effects of UCL-TRO-1938 at these doses.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3Kα

Compound Identifiers

PubChem CID

166451134