UCK2-IN-20874830

SKU: orb1740982

Description

UCK2 Inhibitor-2 is a potent and selective non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), exhibiting an IC50 of 3.8 µM. It effectively blocks cellular nucleoside salvage pathways, making it a valuable chemical probe for studying pyrimidine metabolism in cancer research and other biological contexts both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 866842-71-9
• MW: 497.57
• Purity: 98.76% (May vary between batches)
• Formula: C₂₈H₂₃N₃O₄S
• SMILES: O=C(O)C=1C=CC=C(C1)NC(=O)CSC=2N=C(N=C3OC=4C(=CC=CC4CC32)C)C=5C=CC(=CC5)C
• Target: Dehydrogenase

Bioactivity

• Target IC50:
  UCK2 (K562 cells):3.8 μM
• In Vitro:
  UCK2 Inhibitor-2 (compound 20874830) inhibits UCK2 with an IC₅₀ of 3.8 μM, and at 50 μM, suppresses uridine salvage by 52% in K562 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UCK2 Inhibitor-2, UCK2-IN 20874830, UCK2-IN-2, UCK2-IN20874830

Compound Identifiers

PubChem CID

2138420