UCB-9260

SKU: orb1308746

Description

UCB-9260 is a small molecule inhibitor that attenuates TNF signaling by stabilizing an asymmetric conformation of the TNF trimer. This mechanism makes it a valuable research tool for studying TNF-mediated inflammation in both cellular and animal models of autoimmune and inflammatory diseases.

Research Area

Cell Biology

Key Properties

• CAS Number: 1515888-53-5
• MW: 423.51
• Purity: 99.65% (May vary between batches)
• Formula: C₂₆H₂₅N₅O
• SMILES: Cc1ccc(C)c(Cn2c(nc3ccc(cc23)-c2cnn(C)c2)C(O)c2ccncc2)c1
• Target: TNF
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.81 mM);DMSO:81.7 mg/mL (192.91 mM)

Bioactivity

• Target IC50:
  NF-κB:202 nM|TNF (human):116 nM|TNF (mouse):120 nM
• In Vivo:
  UCB-9260 (150 mg/kg; p.o.) treatment twice daily for 7 days shows a significant reduction of the clinical score. In adult male Balb/c mice, UCB-9260 (10-300 mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment.
• In Vitro:
  In Hek-293 cells, UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation. UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tumor Necrosis Factor Receptor, trimer, UCB 9260, UCB9260, UCB-9260, selective, TNFR, TNF, TNF Receptor, rheumatoid, arthritis, asymmetric, autoimmune, cytotoxicity, cytokine, inhibit, Inhibitor, neutrophil

Compound Identifiers

PubChem CID

72700327