UC-764864

SKU: orb2278179

Description

UC-764864 is a selective UBE2N inhibitor that blocks E1-UBE2N thioester transfer, reducing UBE2N ubiquitination. It inhibits innate immune signaling and demonstrates cytotoxic effects in MDS/AML cell lines and primary cells, making it a valuable tool for leukemia research.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 278806-03-4
• MW: 322.42
• Purity: 99.30% (May vary between batches)
• Formula: C₁₉H₁₈N₂OS
• SMILES: O=C(C=CSC1=NC=2C=C(C=CC2N1)C)C3=CC=C(C=C3)CC
• Target: E1/E2/E3 Enzyme
• Solubility: DMSO:100 mg/mL (310.15 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E3Enzyme, E3 Enzyme, E2Enzyme, E2 Enzyme, E1Enzyme, E1 Enzyme, UBE2N

Compound Identifiers

PubChem CID

2825864