UC-514321

SKU: orb1308747

Description

UC-514321 is a small molecule STAT3/5 inhibitor that downregulates TET1 expression. It demonstrates efficacy against acute myeloid leukemia (AML) in both cellular and animal models, showing promising therapeutic potential with a favorable toxicity profile. This compound is a valuable research tool for investigating oncogenic signaling and epigenetic regulation in hematological malignancies.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 299420-83-0
• MW: 441.56
• Purity: 98.50% (May vary between batches)
• Formula: C₂₆H₃₅NO₅
• SMILES: CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(N1CCOCC1)c1cc2OCOc2cc1O
• Target: Apoptosis,STAT,DNA Methyltransferase
• Solubility: H2O:50 mg/mL (113.23 mM);DMSO:25 mg/mL (56.62 mM)

Bioactivity

• In Vivo:
  In AML mice models, UC-514321 (2.5 mg/kg, i.p., once per day, for 10 days) exhibits more potent anti-tumor activity than NSC370284.
• In Vitro:
  UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently.UC-514321 increases apoptosis in AML cells not in normal HSPCs.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, AML, acute, leukemia, Inhibitor, inhibit, myeloid, low, STAT3, STAT, toxicity, UC 514321, UC514321, UC-514321

Compound Identifiers

PubChem CID

339892