UC-112

SKU: orb1706496

Description

UC-112 is a novel and potent small molecule inhibitor of IAPs (Inhibitor of Apoptosis Proteins). It demonstrates robust anti-proliferative activity in vitro, with IC50 values ranging from 0.7 to 3.4 µM in human melanoma and prostate cancer cell lines. This compound is a valuable research tool for investigating apoptosis pathways and cancer biology in cellular models.

Research Area

Cell Biology

Key Properties

• CAS Number: 383392-66-3
• MW: 348.4382
• Purity: 99.54% (May vary between batches)
• Formula: C₂₂H₂₄N₂O₂
• SMILES: OC1=C(CN2CCCC2)C=C(COCC2=CC=CC=C2)C2=CC=CN=C12
• Target: IAP,Others,Apoptosis
• Solubility: DMSO:8 mg/mL (22.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.87 mM)

Bioactivity

• In Vivo:
  UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo .
• In Vitro:
  UC-112 also effectively inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UC 112, UC112, UC-112

Compound Identifiers

PubChem CID

3426979