Ubiquitination-IN-1

SKU: orb1308977

Description

Ubiquitination-IN-1 is a potent small molecule inhibitor that disrupts the Cks1-Skp2 interaction and inhibits ubiquitination with an IC50 of 0.17 µM. This compound is a valuable research tool for studying cell cycle regulation, protein degradation, and has been utilized in both in vitro and in vivo cancer research models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1819330-15-8
• MW: 429.42
• Purity: 99.88% (May vary between batches)
• Formula: C₂₁H₁₄F₃N₃O₂S
• SMILES: FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1ccc(-c2cccnc2)c2cccnc12
• Target: E1/E2/E3 Enzyme,Others
• Solubility: DMSO:60 mg/mL (139.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.66 mM)

Bioactivity

• In Vitro:
  Ubiquitination-IN-1 inhibits A549 and HT1080 cells (IC50s of 0.91 and 0.4 μM, respectively).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, interaction, E1 activating enzyme, E2 conjugating enzyme, E1/E2/E3 Enzyme, E3 ligating enzyme, degradation, Cksl, protein-protein, Skp2, suppressors, tumor, Ubiquitin activating enzyme, ubiquitination, Ubiquitination IN 1, UbiquitinationIN1, Ubiquitination-IN-1, Ubiquitin ligase, Ubiquitin conjugating enzyme

Compound Identifiers

PubChem CID

118873492