Ub4ix

SKU: orb2663302

Description

Ub4ix is a dual-action inhibitor of deubiquitinating enzymes (DUBs) and the 26S proteasome, which stabilizes K48-linked ubiquitin chains and blocks protein degradation. With an IC50 of 1.6 µM, it induces apoptosis and reduces viability in HeLa cells, making it a valuable tool for studying proteasomal regulation in cancer research.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• Target: Apoptosis|||Proteasome
• CAS Number: 2396736-46-0
• MW: 1767.91
• Formula: C₈₄H₁₀₆N₁₈O₂₃S
• SMILES: C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CC=4C=5C(NC4)=CC=CC5)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC6=CC=C(O)C=C6)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC=7C=8C(NC7)=CC=CC8)NC(=O)CSC[C@@H](C(NCC(N)=O)=O)NC(=O)[C@]([C@H](CC)C)(NC3=O)[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172638602