U-104

SKU: orb1306733

Description

U-104 (NSC-213841) is a potent and selective small molecule inhibitor of carbonic anhydrase isoforms IX (Ki=45.1 nM) and XII (Ki=4.5 nM). It is a valuable research tool for studying tumor acidosis and hypoxia in cancer biology, with applications in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 178606-66-1
• MW: 309.32
• Purity: >99.99% (May vary between batches)
• Formula: C₁₃H₁₂FN₃O₃S
• SMILES: NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(F)cc2)cc1
• Target: Carbonic Anhydrase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.47 mM);DMSO:40 mg/mL (129.32 mM)

Bioactivity

• Target IC50:
  CA XII:4.5 nM(Ki)|CA IX:45.1 nM(Ki)
• In Vivo:
  UNC1215 increased cell mobility and point mutations of the GFP-L3MBTL3 fusion protein, interfered with the Kme-binding function of the GFP-L3MBTL3 phenotypic mimic, and affected the localization of UNC1215.UNC1215 (30 μM) did not affect the tandem Tudor domain of UHRF1, the chromatin domain of CBX7, and the PHD domain of JARID1A. In MCF7,22RV1 and IMR90 cells, UNC0631 significantly reduced H3K9me2 levels. Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%).
• In Vitro:
  UNC1215 increased cell mobility and point mutations of the GFP-L3MBTL3 fusion protein, interfered with the Kme-binding function of the GFP-L3MBTL3 phenotypic mimic, and affected the localization of UNC1215.UNC1215 (30 μM) did not affect the tandem Tudor domain of UHRF1, the chromatin domain of CBX7, and the PHD domain of JARID1A. In MCF7,22RV1 and IMR90 cells, UNC0631 significantly reduced H3K9me2 levels. Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CAXII, 4T1, CarbonicAnhydrase, Carbonic anhydrase IX, Carbonic anhydrase I, Carbonic anhydrase II, Carbonate dehydratase, Carbonic Anhydrase, CAI, CAII, CAIX, Inhibitor, exosome, MST 104, MST104, MST-104, inhibit, NSC-213841, NSC213841, LM2-4, NSC 213841, SLC0111, SLC-0111, SLC 0111, U 104, U104, U-104

Compound Identifiers

PubChem CID

310360