U-104

SKU: orb1306733

Description

U-104

Research Area

Metabolism Research

Key Properties

• CAS Number: 178606-66-1
• MW: 309.32
• Purity: 99.88%
• Formula: C₁₃H₁₂FN₃O₃S
• SMILES: NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(F)cc2)cc1
• Target: Carbonic Anhydrase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.47 mM);DMSO:40 mg/mL (129.32 mM)

Bioactivity

• Target IC50:
  CA XII:4.5 nM(Ki)|CA IX:45.1 nM(Ki)
• In Vivo:
  UNC1215 increased cell mobility and point mutations o the GFP-L3MBTL3 fusion protein, interfered wit the Kme-binding function o the GFP-L3MBTL3 phenotypic mimic, and affecte the localization of UNC1215.UNC1215 (30 μM) did not affec the andem Tudor domain of UHRF1 the chromatin domain of CBX7, an the PHD domain of JARID1A. In MCF7,22RV1 and IMR90 cells, UNC0631 significantly reduced H3K9me2 levels. Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%).
• In Vitro:
  UNC1215 increased cell mobility and point mutations o the GFP-L3MBTL3 fusion protein, interfered wit the Kme-binding function o the GFP-L3MBTL3 phenotypic mimic, and affecte the localization of UNC1215.UNC1215 (30 μM) did not affec the andem Tudor domain of UHRF1 the chromatin domain of CBX7, an the PHD domain of JARID1A. In MCF7,22RV1 and IMR90 cells, UNC0631 significantly reduced H3K9me2 levels. Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CAXII, 4T1, CarbonicAnhydrase, Carbonic anhydrase IX, Carbonic anhydrase I, Carbonic anhydrase II, Carbonate dehydratase, Carbonic Anhydrase, CAI, CAII, CAIX, Inhibitor, exosome, MST 104, MST104, MST-104, inhibit, NSC-213841, NSC213841, LM2-4, NSC 213841, SLC0111, SLC-0111, SLC 0111, U 104, U104, U-104

Compound Identifiers

PubChem CID

310360