Tyrphostin AG1433

SKU: orb1308979

Description

Tyrphostin AG1433 is a dual inhibitor of the PDGFRβ and VEGFR-2 (KDR) tyrosine kinases with IC50 values of 5.0 μM and 9.3 μM, respectively. This compound is used in biochemical and cellular research to study angiogenesis and tumor growth pathways in both in vitro and in vivo experimental models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 168835-90-3
• MW: 266.29
• Purity: 98.47% (May vary between batches)
• Formula: C₁₆H₁₄N₂O₂
• SMILES: Cc1cc2ncc(nc2cc1C)-c1ccc(O)c(O)c1
• Target: PDGFR,VEGFR
• Solubility: DMSO:3.06 mg/mL (11.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.76 mM)

Bioactivity

• Target IC50:
  FLK1:9.3 μM|PDGFRβ:5 μM
• In Vivo:
  Tyrphostin AG1433 is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos, and prevents the formation of new yessels under the pellets.
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• In Vitro:
  In glioblastoma cells, Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cytotoxicity, AG 1433, AG1433, AG-1433, angiogenesis,tyrosine, ATM, Flk1, Flk-1, Inhibitor, inhibit, KDR, kinases, Platelet-derived growth factor receptor, PDGFR, PDGFRβ, SU 1433, SU1433, SU-1433, Vascular endothelial growth factor receptor, VEGFR, VEGFR2, VEGFR-2, Tyrphostin AG 1433, Tyrphostin AG1433, Tyrphostin AG-1433

Compound Identifiers

PubChem CID

2050