Tyrphostin AG 879

SKU: orb1223284

Description

AG-879 is a tyrphostin compound that inhibits nerve growth factor-dependent TrkA tyrosine phosphorylation in PC-12 cells, HER2-ErbB2 kinase in several breast and ovarian cancer cell lines, and the VEGF receptor FLK1. It decreases cellular proliferation in human muscular sarcoma cell lines.

Key Properties

• CAS Number: 148741-30-4
• MW: 316.46
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₄N₂OS
• SMILES: Oc1c(C(C)(C)C)cc(/C=C(\C#N)/C(=S)N)cc1C(C)(C)C
• Target: ALK
• Solubility: DMSO : ≥ 30 mg/mL. 94.80 mM

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells. Concentration: 0.5 μM, 5 μM, 20 μM and 50 μM Incubation time: 48 hours. Result: Significantly and dose dependently decreased cell proliferation in all the cell lines. Apoptosis Analysis Cell line: HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells. Concentration: 0.5 μM, 5 μM, 20 μM and 50 μM Incubation time: 48 hours. Result: Induced a dose-dependent increase in apoptosis.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Val-boroPro (mesylate) | PT100 (mesylate)

Quick Database Links

Gene Symbol

ALK