[Tyr22] - a - CGRP (22 - 37), rat

SKU: orb3053956

Description

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and adenylate cyclase. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system.

Key Properties

• CAS Number: 198277-54-2
• MW: 1785.99
• Purity: >98% (HPLC)
• Formula: C₈₂H₁₂₀N₂₀O₂₅
• Solubility: DMSO : 100 mg/mL (55.99 mM; ultraphonic; )

Bioactivity

• In Vitro:
  Calcitonin Gene Related Peptide (CGRP) in humans, exists in two forms: CGRP alpha (α-CGRP or CGRP I), and CGRP beta (β-CGRP or CGRP II). [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat shows the receptor binding affinity mainly depending on the carboxyterminal end while the ability to stimulate adenylate cyclase (AC) enzyme mainly depending on the aminoterminal end.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only