Tyr-Gly-Gly-Phe-Met-OH

SKU: orb1299974

Description

Met-Enkephalin (Tyr-Gly-Gly-Phe-Met-OH) is an endogenous opioid peptide that binds to opioid receptors. It is widely used in neuroscience and oncology research to study receptor signaling and has been investigated in vitro and in vivo for its role in modulating pain and inhibiting tumor cell proliferation.

Research Area

Metabolism Research, Metabolism Research; Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 58569-55-4
• MW: 573.66
• Purity: 99.74% (May vary between batches)
• Formula: C₂₇H₃₅N₅O₇S
• SMILES: CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
• Target: Opioid Receptor
• Solubility: DMSO:81.67 mg/mL (142.37 mM)

Bioactivity

• In Vitro:
  Tyr-Gly-Gly-Phe-Met-OH,as know as Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. Clinical trial studies in cancer patients have shown that MENK activates immune cells directly and by inhibiting regulatory T-cells (Tregs). MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tyr Gly Gly Phe Met OH, TyrGlyGlyPheMetOH, Tyr-Gly-Gly-Phe-Met-OH, inhibit, Opioid Receptor, OpioidReceptor, Methionine enkephalin, Met-Enkephalin, Inhibitor

Compound Identifiers

PubChem CID

443363