TYK2-IN-12

SKU: orb1687593

Description

TYK2-IN-12 is a potent and selective TYK2 inhibitor with a Ki of 0.51 nM, demonstrating oral activity. It effectively blocks IL-12-induced IFNγ production in human and mouse whole blood assays, supporting its use as a research tool for investigating autoimmune conditions such as psoriasis in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2244061-66-1
• MW: 434.44
• Formula: C₂₄H₂₀F₂N₄O₂
• SMILES: N(C1=C2C(=NC(=C1)C3=C(F)C=CC=C3F)CNC2=O)C4=CC=C(C(=O)N5CCCC5)C=C4
• Target: Others,IFNAR,JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138739713