TXNIP-IN-1

SKU: orb1308983

Description

TXNIP-IN-1 is a small molecule inhibitor that disrupts the TXNIP-TRX interaction. It is a research tool used to study the role of this complex in metabolic diseases like diabetes, as well as in cardiovascular and inflammatory conditions, in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1268955-50-5
• MW: 248.23
• Purity: 99.11% (May vary between batches)
• Formula: C₁₂H₁₂N₂O₄
• SMILES: CC(C)C(N1C(=O)c2ccncc2C1=O)C(O)=O
• Target: Arrestin,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.06 mM);DMSO:40 mg/mL (161.14 mM)

Bioactivity

• In Vitro:
  TXNIP-IN-1 bocks high glucose (HG induced) TXNIP-TRX complex formation.In monocytes, TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF . In THP1 cells,TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression . TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages. In MIN6 cells, TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels . TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in human pancreas 1.1B4 beta cells. TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose. TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

diabetes, inhibit, Inhibitor, protein, thioredoxin-interacting, thioredoxin, TXNIP, TXNIP IN 1, TXNIPIN1, TXNIP-IN-1, TXNIP-TRX complex, TRX

Compound Identifiers

PubChem CID

47001822