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TX1-85-1
Catalog Number: orb1307642
| Catalog Number | orb1307642 |
|---|---|
| Category | Small Molecules |
| Description | TX1-85-1 |
| CAS Number | 1603845-32-4 |
| Purity | 98.12% |
| MW | 580.68 |
| SMILES | CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12 |
| Formula | C32H36N8O3 |
| Biological Activity | TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
