TVB-3166

SKU: orb1307644

Description

TVB-3166

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1533438-83-3
• MW: 384.47
• Purity: 99.57% (May vary between batches)
• Formula: C₂₄H₂₄N₄O
• SMILES: CC=1C(=CC(C(=O)N2CC(C2)C3=CC=C(C#N)C=C3)=C(C)C1)C=4C(C)=C(C)NN4
• Target: Apoptosis,Fatty Acid Synthase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.2 mM);DMSO:50 mg/mL (130.05 mM)

Bioactivity

• Target IC50:
  FASN:42 nM|Cellular palmitate synthesis:81 nM
• In Vivo:
  TVB-3166 (Oral gavage; 30-100 mg/kg/day) has the concentration is approximately 3-fold higher in plasma than the tumor. TVB-3166 (Oral gavage; 30-100 mg/kg/day) inhibits xenograft tumor growth. The 100 and 30 mg/kg groups had plasma and tumor concentrations of 7 and 2.9 μM, respectively .
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• In Vitro:
  TVB-3166 (0.2 μM; 48 hours) inhibits β-catenin pathway signal transduction and transcriptional activity. TVB-3166 (0.02 or 0.20 μM; 7 days) suppresses palmitate synthesis and tumor cell viability in a dose-dependent manner. TVB-3166 (0.001-10 μM; 24 hours) induces cell death in CALU-6 non-small-cell lung tumor cells (cellular IC50: 0.10 μM) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cellular palmitate synthesis, Apoptosis, Inhibitor, FASN, FattyAcidSynthase, Fatty Acid Synthase, Fatty Acid Synthase (FASN), inhibit, TVB3166, TVB-3166, TVB 3166

Compound Identifiers

PubChem CID

72947731