TV 3279

SKU: orb1744041

Description

TV-3279 is a novel ChE-MAI inhibitor with neuroprotective properties. It functions by upregulating anti-apoptotic proteins like PKC, Bcl-2, Bcl-x, and SOD, while inhibiting the pro-apoptotic nuclear translocation of GAPDH in PC-12 and neuroblastoma cell models. This small molecule is a useful research tool for studying neuroprotection and apoptosis mechanisms in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 209394-29-6
• MW: 272.34
• Purity: 97.00% (May vary between batches)
• Formula: C₁₆H₂₀N₂O₂
• SMILES: N(CC#C)[C@@H]1C=2C(CC1)=CC=C(OC(N(CC)C)=O)C2
• Target: Cholinesterase (ChE),Bcl-2 Family,PKC
• Solubility: DMSO:2.73 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  Chronic TV3279 (26 mg kg-1 for 21 days; rats) similarly inhibited ∼50% of striatal ChE activity but did not affect MAO activity or amine levels. Accordingly, chronic TV3279 abolished the ability of TCP to initiate L-dopa-induced hyperactivity. In contrast, chronic as well as acute treatments with TV3279 reduced spontaneous motor activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PKC, TV 3279, TV3279, TV-3279, Bcl-2

Compound Identifiers

PubChem CID

6918437