Tuspetinib hydrate

SKU: orb2565107

Description

Tuspetinib hydrate is a potent, orally available, and selective type I FLT3 inhibitor with low nM IC₅₀ values against FLT3 WT, ITD, and D835Y mutants. It disrupts key signaling pathways (e.g., STAT5, ERK) and has demonstrated activity in inhibiting proliferation and inducing apoptosis in FLT3-mutant leukemia cells in preclinical studies.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2758339-04-5
• MW: 519.08
• Formula: C₂₉H₃₅ClN₆O
• SMILES: ClC=1C(C=2C=3C(NC2)=CC(C)=CC3)=NC(NC4=CC(=CC(CN5C[C@@H](C)N[C@@H](C)C5)=C4)C6CC6)=NC1.O
• Target: FLT,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135390909