TUG-1375

SKU: orb1299498

Description

TUG-1375 is a selective agonist for the free fatty acid receptor 2 (FFAR2/GPR43). This small molecule is utilized in research to investigate FFAR2's role in immune modulation and metabolism, with applications in both in vitro cellular assays and in vivo metabolic studies.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2247372-59-2
• MW: 442.92
• Purity: 99.41%
• Formula: C₂₂H₁₉ClN₂O₄S
• SMILES: Cc1noc(C)c1-c1ccc(cc1)C(=O)N1[C@@H](CS[C@@H]1c1ccccc1Cl)C(O)=O
• Target: GPCR
• Solubility: DMSO:45 mg/mL (101.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.52 mM)

Bioactivity

• In Vitro:
  TUG-1375, a compound with significantly increased potency (7-fold in a cAMP assay) and reduced lipophilicity (50-fold reduced clogP) relative to the pyrrolidine lead structure. TUG-1375 induce human neutrophil mobilization and to inhibit lipolysis in murine adipocytes.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Free Fatty Acid Receptor, FFAR, FFA2, Inhibitor, inhibit, TUG 1375, TUG1375, TUG-1375

Compound Identifiers

PubChem CID

138319694