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Tubulin/LSD1-IN-1

SKU: orb3135129

Description

Tubulin/LSD1-IN-1 is a potent dual inhibitor of tubulin polymerization and LSD1 (IC50 = 1.72 μM), exhibiting broad-spectrum antiproliferative activity against cancer cell lines. By targeting the colchicine binding site, it disrupts the microtubule network in gastric cancer cells. Tubulin/LSD1-IN-1 enhances methylation levels of H3K4me1/2 and H3K9me2/3, facilitating epigenetic regulation. It induces G2/M phase arrest, promotes apoptosis, and effectively inhibits colony formation in gastric cancer cells.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research; Cell Biology, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

TargetWee1,Microtubule Associated,Apoptosis,Caspase,Histone Demethylase,Bcl-2 Family

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information