Tubulin polymerization/P-gp-IN-1

SKU: orb3173666

Description

Tubulin polymerization/P-gp-IN-1 is a dual inhibitor targeting both tubulin polymerization and P-gp. It disrupts tubulin polymerization, inducing G2/M phase arrest and apoptosis (apoptosis). By inhibiting P-gp's efflux function, it reverses multidrug resistance (MDR). Tubulin polymerization/P-gp-IN-1 has dual roles: direct antitumor activity and reversal of P-gp-mediated cisplatin resistance. It binds stably to the tubulin CBS domain (ΔG = −12.4 kcal/mol) and the P-gp hydrophobic cavity (ΔG = −10.8 kcal/mol). Tubulin polymerization/P-gp-IN-1 is applicable for research on drug-resistant cervical cancer.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• Target: P-gp,Microtubule Associated,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P-gp,Microtubule Associated,Apoptosis