Tubulin polymerization-IN-85

SKU: orb3174297

Description

Tubulin polymerization-IN-85 (Compound C21) is a microtubule polymerization inhibitor with an IC50 value of 1.59 μM, targeting the colchicine binding site. It exhibits antiproliferative activity against HeLa, HepG2, MCF-7, and A549 cells with IC50 values of 0.08, 0.21, 0.27, and 0.32 μM, respectively, while demonstrating low toxicity to normal renal epithelial 293T cells (IC50 value of 187 μM). Tubulin polymerization-IN-85 induces G2/M phase arrest and triggers apoptosis in cancer cells. It downregulates the expression of Bcl-2, Bcl-xl, Mcl-1, Cyclin B1, cdc25, and cdc2 proteins, and upregulates P53, P21, Bad, and Bax levels. This compound is applicable in cancer research, such as cervical cancer studies.

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Key Properties

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Target	Apoptosis,CDK,MDM-2/p53,Microtubule Associated,Bcl-2 Family

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Apoptosis,CDK,MDM-2/p53,Microtubule Associated,Bcl-2 Family

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