Tubulin polymerization-IN-84

SKU: orb3172902

Description

Tubulin polymerization-IN-84 can inhibit the polymerization process of tubulin (Tubulin) by targeting the colchicine-binding pocket, with an IC50 value of 10.9 μM. Tubulin polymerization-IN-84 exhibits antiproliferative activity against four cell lines, namely Jurkat, B16-F10, HCT116 and MDA-MB-231, with corresponding IC50 values of 60 nM, 380 nM, 138 nM and 1.054 μM, respectively. In B16-F10 cells, Tubulin polymerization-IN-84 can induce G2/M phase cell cycle arrest and further trigger cell apoptosis. In addition, in the B16-F10 melanoma model, it can effectively inhibit the growth of tumor tissue; when combined with PD-L1 monoclonal antibody, it can also enhance the in vivo anti-tumor immune response, and can be used in the related research fields of T-cell acute lymphoblastic leukemia, melanoma, colon cancer and breast cancer.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2982893-14-9
• MW: 374.43
• Purity: 99.86% (May vary between batches)
• Formula: C₂₃H₂₂N₂O₃
• SMILES: N=1C(=CN2C=CC=C(C=3C=C(OC)C(OC)=C(OC)C3)C12)C=4C=CC(=CC4)C
• Target: Cell Cycle Arrest,Microtubule Associated,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Cell Cycle Arrest,Microtubule Associated,Apoptosis