Tubulin polymerization-IN-68

SKU: orb2665452

Description

Tubulin polymerization-IN-68 is a potent small molecule tubulin polymerization inhibitor that induces apoptosis via PARP-1 and caspase-3 upregulation. It demonstrates potent in vitro anticancer activity against HepG2 cells (IC50 = 93 nM) and has shown significant oral efficacy in reducing HepG2 xenograft tumor growth in nude mouse models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 2924156-96-5
• MW: 263.29
• Formula: C₁₆H₁₃N₃O
• SMILES: O=C1NC(NC=2C=CC=CC12)C=3C=CC=4NC=CC4C3
• Target: Apoptosis,Caspase,PARP,Microtubule Associated

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172638543