Tubulin-IN-51

SKU: orb3135671

Description

Tubulin-IN-51 is an orally active tubulin inhibitor with an IC50 of 31 nM. It promotes tubulin polymerization in vitro and does not competitively bind with Paclitaxel. Tubulin-IN-51 inhibits the binding of Vinblastine to tubulin and suppresses tumor growth in various nude mouse xenograft models, including those using A549 human non-small cell lung cancer (NSCLC) cells and U87-MG human glioblastoma.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 849550-36-3
• MW: 464.82
• Formula: C₁₈H₁₈ClF₅N₆O
• SMILES: N([C@@H](C(F)(F)F)C)C1=C(C(Cl)=NC=2N1N=CN2)C3=C(F)C=C(OCCCNC)C=C3F
• Target: Apoptosis,Microtubule Associated

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Microtubule Associated