Tuberin Antibody

• Catalog Number: orb1730186
• Category: Antibodies
• Description: Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: FC, IHC, WB
• Reactivity: Human, Mouse, Rat
• Isotype: Rabbit IgG
• Immunogen: A synthetic peptide of human Tuberin
• Dilution range: WB: 1/500-1/1000; IHC: 1/50-1/100; RCM: 1/50-1/100
• Conjugation: Unconjugated
• MW: Calculated MW: 201 kDa; Observed MW: 201 kDa
• Entrez: 7249
• UniProt ID: P49815
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin
• Alternative names: TSC2; Tuberous sclerosis 2 homolog protein; Tubero
• Note: For research use only
• Expiration Date: 12 months from date of receipt.