TTK/PLK1-IN-1

SKU: orb2814660

Description

TTK/PLK1-IN-1 is a potent dual inhibitor of TTK (IC₅₀ = 7 nM) and PLK1 (IC₅₀ = 72 nM). It functions by disrupting the spindle assembly checkpoint, leading to mitotic arrest and inhibition of cancer cell proliferation, making it a valuable tool for oncology research in vitro.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1817791-70-0
• MW: 523.63
• Purity: 97.39%
• Formula: C₃₀H₃₃N₇O₂
• SMILES: O=C(NC=1C(=CC=CC1C)C)C=2C=CN3C4=NC(=NC=C4CCC23)NC5=CC=C(C=C5OC)N6CCNCC6
• Target: PLK,Kinesin,Tyrosine Kinases

Bioactivity

• Target IC50:
  PLK1:72 nM|TTK:7 nM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118437458