TTBK1-IN-2

SKU: orb1301172

Description

TTBK1-IN-2 is a potent small molecule inhibitor of Tau-Tubulin Kinase 1 (TTBK1), exhibiting IC50 values of 0.24 µM and 4.22 µM. It effectively reduces pathological TDP-43 phosphorylation in both cellular models and in vivo, as demonstrated in transgenic mouse spinal cords, making it a valuable research tool for neurodegenerative disease studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 2765453-51-6
• MW: 336.77
• Purity: 99.83% (May vary between batches)
• Formula: C₁₈H₁₃ClN₄O
• SMILES: Clc1ccc(Oc2ccc(Nc3ncnc4[nH]ccc34)cc2)cc1
• Target: Microtubule Associated,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.94 mM);DMSO:55 mg/mL (163.32 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Microtubule Associated, MicrotubuleAssociated, tau, TTBK1-IN-2, Tubulin

Compound Identifiers

PubChem CID

162679313