TT01001

SKU: orb1305405

Description

TT01001 is a selective mitoNEET agonist that ameliorates mitochondrial dysfunction, thereby reducing oxidative stress and neuronal apoptosis. Its application in type II diabetes research is supported by studies demonstrating protective effects in cellular and animal models of metabolic disease.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1022367-69-6
• MW: 376.3
• Purity: 99.93%
• Formula: C₁₅H₁₉Cl₂N₃O₂S
• SMILES: C(OCC)(=O)N1CCC(NC(NC2=CC(Cl)=CC(Cl)=C2)=S)CC1
• Target: Apoptosis,Mitochondrial Metabolism,ROS,Reactive Oxygen Species
• Solubility: DMSO:55 mg/mL (146.16 mM)

Bioactivity

• In Vivo:
  In type II diabetes model db/db mice, TT01001 improved hyperglycemia, hyperlipidemia, and glucose intolerance, and its efficacy was equivalent to that of pioglitazone, without the pioglitazone-associated weight gain. Mitochondrial complex II + III activity of the skeletal muscle was significantly increased in db/db mice. TT01001 significantly suppressed the elevated activity of the complex II + III.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TT 01001, TT01001, TT-01001, Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate, Mitochondrial Metabolism, MitochondrialMetabolism, mitoNEET

Compound Identifiers

PubChem CID

3778113