TT-10

SKU: orb1739720

Description

TT-10 (TAZ-K) is a small molecule activator of the YAP-TEAD transcriptional complex. It is a valuable research tool for studying cardiac regeneration and repair in models of heart disease involving cardiomyocyte loss, with applications in both in vitro and in vivo experimental systems.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2230640-94-3
• MW: 283.35
• Purity: 99.76% (May vary between batches)
• Formula: C₁₁H₁₀FN₃OS₂
• SMILES: Nc1nc(NCC=C)sc1C(=O)c1ccc(F)s1
• Target: YAP
• Solubility: 2% DMSO+40% PEG300+5% Tween 80+53% Saline:1.25 mg/mL (4.41 mM);DMSO:60 mg/mL (211.75 mM)

Bioactivity

• In Vivo:
  TT-10 (2 μM, 10 μM, 20 μM, or 100 μM ; 48 h ; intraperitoneal injections) was administered to infarcted mouse hearts, the treatment promoted cardiomyocyte proliferation and was associated with declines in infarct size 1 week after administration, but cardiac function worsened at later time points.
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• In Vitro:
  TT-10 (10 μmol/L ; 48 h) significantly promoted cell cycle activation and cell division of human induced pluripotent stem cell (hiPSC) derived cardiomyocytes (hiPSCM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TAZ-K, TT 10, TT10, TT-10, YAP–TEAD

Compound Identifiers

PubChem CID

134827875