Tryptamine hydrochloride

SKU: orb2946028

Description

Tryptamine hydrochloride is a monoamine alkaloid derived from tryptophan, acting as an agonist at 5-HT4, TAAR1, and AHR receptors. Its CNS activity and potential blood-brain barrier permeability make it a valuable tool for in vitro and in vivo neuropharmacology research, particularly in studying serotonin signaling and trace amine-associated receptors.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 343-94-2
• MW: 196.68
• Purity: 99.89% (May vary between batches)
• Formula: C₁₀H₁₃ClN₂
• SMILES: Cl.NCCC1=CNC=2C=CC=CC21
• Target: 5-HT Receptor,AhR,Endogenous Metabolite
• Solubility: DMSO:80 mg/mL (406.75 mM);H2O:50 mg/mL (254.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (16.78 mM)

Bioactivity

• In Vivo:
  Subcutaneous injection of 2 mg Tryptamine hydrochloride (in 0.5 mL) in rats led to a marked reduction in histamine content at the injection site. Repeated intraperitoneal injections totaling 13 mg over 3 days significantly decreased histamine levels in the skin (by 30-46%) and diaphragm (by 26%), indicating systemic histamine release.
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• In Vitro:
  In perfused cat skin flaps and gastrocnemius muscles, arterial injection of tryptamine hydrochloride (2 mg/0.5 mL) induced significant histamine release (up to 283 µg per injection), along with vasoconstriction and edema formation. This activity confirms that Tryptamine hydrochloride acts as a histamine-releasing agent in vitro.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine HCl

Compound Identifiers

PubChem CID

67652