TrxR/EGFR-IN-1

SKU: orb2944579

Description

TrxR/EGFR-IN-1 (Compound L1Au2) is a dual inhibitor effective against gefitinib-sensitive and -resistant lung cancer models. It induces ferroptosis via GPX4 degradation and triggers immunogenic cell death through endoplasmic reticulum stress, applicable for studying drug resistance mechanisms in both cellular and animal studies.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3038386-42-1
• MW: 710.878
• Formula: C₂₄H₂₄AuClFN₆O₂P
• SMILES: FC1=CC=C(C=C1Cl)NC=2N=CN=C3C=C(OC)C(OCC#[C-][Au+][P]45CN6CN(CN(C6)C4)C5)=CC32
• Target: EGFR,Apoptosis,Ferroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,Apoptosis,Ferroptosis